Abstract
Neonatal hypothyroidism was induced in rat pups by injecting 131I within two days of birth and the effects on kinetic properties of Na +, K +-ATPase from synaptic plasma membranes were examined. Neonatal hypothyroidism resulted in a generalized decrease in V max with ATP, Na +, K + and Mg 2+ together with an increase in the K m for ATP, appearance of a low affinity component for Na + and allosteric characteristic for the Mg 2+-dependent activity at high Mg 2+ concentrations. Binding pattern for Na + and Mg 2+ changed. Our results suggest that impairment of Na +, K +-ATPase activity together with altered kinetic properties could be one of the underlying biochemical mechanism leading to central nervous system (CNS) dysfunctions as a consequence of thyroid hormone deprivation during critical stages of brain development.
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