Abstract
Objective: The analysis of clinical-laboratory peculiarities and the dynamics of glycemia clarifying the terms of blood glucose stabilization during the early neonatal period in children having risk factors of the development of such state.Methods: Open, retrospective , continuous, single-center study was conducted. It was aimed at getting preliminary data that is important for planning further tactics of examining newborns having risk factors on hypoglycemia development (kids having large body weight at birth, children whose mothers have diabetes, newborns having intrauterine growth retardation).The target group of the survey included 522 newborns of both genders in the early neonatal period (from 0 to 7 days of life).Results: There is data on the frequency of first indicated hypoglycemia in newborns having risk factors of the development of such state, clinicallaboratory peculiarities, the dynamics of glycemia during early neonatal period, and also the period of blood glucose stabilization (the age of reaching normoglycemia). Neonatal hypoglycemia was detected in 40.2% of examined children. Laboratory manifestation during the first day of life was noticed 62.9% of cases with the further normalization of glucose level in blood in 24 hours in 73.3% of newborns. Significant reduction of blood glucose was observed in 54.8% of cases requiring hypoglycemia therapy with parenteral prescription of 10% glucose solution. Hypoglycemia jugulated against oral correction of 5% glucoses solution in 40.5 % of cases. 4.8% of children got the level of glucose stabilized after introduction of supplementary feeding.Conclusion: The results of the newborns having risk factors on hypoglycemia development (kids having large body weight at birth, children whose mothers have diabetes, newborns having intrauterine growth retardation) examinations are presented. The peculiarities of neonatal hypoglycemia are: the absence of a typical clinical symptoms among 89% of children. Asymptomatic course of hypoglycemia confirms the importance and necessity of glycemia monitoring in the early neonatal period in order to conduct timely and adequate therapy.
Highlights
The analysis of clinical-laboratory peculiarities and the dynamics of glycemia clarifying the terms of blood glucose stabilization during the early neonatal period in children having risk factors of the development of such state
Open, retrospective, continuous, single-center study was conducted. It was aimed at getting preliminary data that is important for planning further tactics of examining newborns having risk factors on hypoglycemia development.The target group of the survey included 522 newborns of both genders in the early neonatal period
Significant reduction of blood glucose was observed in 54.8% of cases requiring hypoglycemia therapy with parenteral prescription of 10% glucose solution
Summary
Цель: анализ клинико-лабораторных особенностей и динамики гликемии с уточнением сроков стабилизации глюкозы крови в раннем неонатальном периоде у детей с факторами риска по развитию данного состояния. Ретроспективное, сплошное, одноцентровое исследование, предназначенное для получения предварительных данных, важных для планирования дальнейшей тактики наблюдения новорожденных детей с факторами риска по развитию гипогликемии (дети с крупной массой тела при рождении, дети от матерей с сахарным диабетом, новорожденные с задержкой внутриутробного развития). В работе содержатся данные по частоте впервые выявленной гипогликемии у новорожденных с факторами риска по развитию данного состояния, клинико-лабораторным особенностям, динамике гликемии в течение раннего неонатального периода, а также сроки стабилизации глюкозы крови (возраст достижения нормогликемии). Представлены результаты наблюдения у новорожденных детей, имеющих факторы риска по развитию гипогликемий (дети с крупной массой тела при рождении, сахарный диабет у матери, новорожденные с задержкой внутриутробного развития). Таранушенко Т.Е., Киселева Н.Г., Беляева Е.А., Донская Т.И.
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