Abstract
The balance between the multiple developing structures and their function probably determines whether a state of health can be achieved at a given gestational age. The diversity of possible influences explains the difficulties in clarifying the etiology of disease states such as necrotizing enterocolitis. Studies of fetal animals but also especially carefully conducted studies in human preterm babies will further advance our understanding of the normal development of small intestinal function and of the influence of external factors such as intercurring clinical problems and therapeutic interventions. It can be expected that using animal models and relatively non-invasive methods in a clinical situation our knowledge regarding the development of gastro-intestinal function will progress and the medical care of perterm infants, especially their nutritional support, will continue to improve.
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