Neonatal fatty acid status and cardiometabolic health at 9 years

Abstract

BackgroundLong chain polyunsaturated fatty acid (LCPUFA) status is associated with risk of cardiovascular diseases in adulthood. We previously demonstrated no effect of LCPUFA supplementation after birth on BP and anthropometrics. Little is known about the association between fatty acid status at birth and cardiometabolic health at older ages. AimTo evaluate associations between docosahexaenoic acid (DHA) and arachidonic acid (AA) levels in the umbilical cord and blood pressure (BP) and anthropometrics at 9years. Study designObservational follow-up study. Multivariable analyses were carried out to adjust for potential confounders. Subjects229 children who took part in a randomized controlled trial (RCT) on the effects of LCPUFA formula supplementation. Outcome measuresBP was chosen as primary outcome; heart rate and anthropometrics as secondary outcomes. ResultsAA levels in the wall of the umbilical vein and artery were negatively associated with diastolic BP (B: vein −0.831, 95% CI: −1.578; −0.083, p=0.030; artery: −0.605, 95% CI: −1.200; −0.010, p=0.046). AA was not associated with systolic BP; DHA not with diastolic nor systolic BP. The AA:DHA ratio in the umbilical vein was negatively associated with diastolic BP (B: −1.738, 95% CI: −3.141; −0.335, p=0.015). Heart rate and anthropometrics were not associated with neonatal LCPUFA status. ConclusionsHigher AA levels and a higher AA:DHA ratio at birth are associated with lower diastolic BP at age 9. This suggests that the effect of LCPUFAs at early age is different from that in adults, where DHA is regarded anti-adipogenic and AA as adipogenic.