Abstract
To evaluate whether estrogen responsiveness influenced by neonatal androgenization, 28 Sherman female rats were injected when 5 days old with either oil, 0, 10, or 1250 μg testosterone propionate (TP) and after reaching maturity, permitted to live in Wahmann activity apparatuses. Daily number of revolutions was recorded while animals were intact, spayed and injected daily first with 0.1 μg and then with 1.0 μg estradiol benzoate (EB). After removal from activity cages, animals were administered either oil or 3.3 μg EB for each of 5 days before uterine sections were taken. The results reveal that running rate and amplitude for each level of EB were inversely proportional to the neonatal TP dosage. Similarly, relative uterus weight after EB replacement was lowest for the 1250 μg TP and highest for the oil-injected rats. It was concluded that neonatal androgen reduces adult responsiveness to estrogen in direct proportion to the amount administered.
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