Abstract
We investigated the relationship of neonatal and maternal serum creatinine (nSCr and mSCr, respectively) with various maternal/infant characteristics at different gestational ages (GA). We reviewed medical records of neonates admitted to NICU. We collected data on birth weight, GA, Apgar scores, medications, etc. Spearman’s test was used to analyze the correlation between serum creatinine and continuous variables, and the Mann-Whitney U and Kruskal-Wallis tests for continuous variables between groups. The changes in nSCr, mSCr, and nSCr/mSCr ratio because of gestational age and the points in gestational changes in trends were estimated using joinpoint trend analysis. From 614 neonate and mother pairs, we found that nSCr was significantly correlated with GA. However, mSCr at >28 wks decreased with GA. The nSCr/mSCr ratio was correlated with GA. In infants born <29 weeks, pregnancy-induced hypertension (PIH) (p = 0.000, β = 0.20) and mSCr (p = 0.000, β = 0.73) were significantly associated with nSCr. In term infants, maternal magnesium administration (p = 0.000, β = 0.25), respiratory distress syndrome (p = 0.013, β = 0.16), PIH (p = 0.005, β = 0.19), and mSCr (p = 0.000, β = 0.33) were significantly associated with nSCr. nSCr reflected mSCr at all gestational ages. The correlation between nSCr and mSCr in preterm infants (p = 0.000, β = 0.74) was stronger than in term infants (p = 0.000, β = 0.34).
Highlights
Renal function is typically estimated by glomerular filtration rate [1]
In infants born at 29–36 wks and term infants, median neonatal serum creatinine levels (nSCr) at birth was significantly higher than maternal serum creatinine (mSCr), respectively (Table 1)
Our study suggested that there was a relationship between nSCr and mSCr levels in Japanese neonates born with or without mother’s complications
Summary
Renal function is typically estimated by glomerular filtration rate (eGFR) [1]. The simplest and most commonly used parameter for eGFR measurement is serum creatinine (SCr) [2]. Lao et al showed that neonatal serum creatinine levels (nSCr) correlated with birth weight (BW) and maternal serum creatinine (mSCr) [3]. Renal function is low at birth, especially in premature infants [4]. Preterm birth is associated with maternal complications. NSCr in preterm infants is influenced by various factors [5,6,7]. While nSCr can be a useful surrogate marker of neonatal renal function, some perinatal complications such as pregnancy-
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