Neonatal administration of fluoxetine did not alter the anxiety indicators, but decreased the locomotor activity in adult rats in the elevated plus-maze

Abstract

The objective of this study was evaluate the anxiety and locomotor activity (LA) in 52 Wistar adult male rats, being 26 treated with fluoxetine (10 mg/Kg - sc) in the neonatal period. These same rats received foot shock (FS) (1.6-mA - 2-s) in the 90th day. The anxiety and LA were appraised by plus-maze. The time spent in the open arms was used as anxiety index and the LA was measured by number of entries in closed arms (NECA) and the total of entries (TE). T-test was used with p<0.05 and expresses data in mean+/-SEM. There were reductions with the fluoxetine group in the NECA (2.35+/-0.33) and in the TE (3.96+/-0.61) compared to the controls (4.65+/-0.52) and (6.96+/-0.94). The neonatal administration of fluoxetine did not alter the anxiety, but reduced the LA in the animals that received FS.