Abstract
The objective of research study was to fabricate neomycin sulphate loaded transferosomal vesicles by modified handshaking technique to increase the permeability of drug through vaginal mucosa. Tween80, span80, tween20, span20, Cremophor EL, brij35, sodium deoxycholate were used at three different concentrations by keeping drug concentration remains constant in all formulations. Stable vesicular formulation was obtained with span80 which is a better intercalatable surfactant in phospholipid layer, results also proved that that the fabricated neomycin sulphate loaded transferosomes were stabilized in terms of zetapotential +5mV homogenously dispersed with PDI value of 0.368 and particle size 152.8nm, entrapment efficiency values are 89.87%. Lipid extrusion test also concluded that fabricated neomycin sulphate loaded transferosomes were highly deformable in nature with deformability index value of 31.8. DSC of freeze dried nanosuspension results revealed that neomycin sulphate loaded transferosomes does not contain any peak related to neomycin sulphate could be due to complete loading of drug into vesicles, X-diffractogram patterns of a freeze dried nanosuspension also revealed that conversion of drug into loose lattice arrangement indicating amorphous nature of drug , in turn imposing loading more quantity of drug.
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