Abstract
Neoabyssomicin A (1) possessing a caged 6/6/6 ring system fused with two additional 6/9 lactone rings, neoabyssomicin B (2) featuring a 12-membered macrolactone ring and its seco-form, neoabyssomicin C (3), along with the known abyssomicin 2 (4) and 4 (5), were discovered from the deep-sea derived Streptomyces koyangensis SCSIO 5802. The structures of 1–3 were elucidated on the basis of MS, NMR spectroscopic and X-ray diffraction data analyses. A plausible biogenetic relationship of 1–5 is proposed. Additionally, compound 4 shows antibacterial activities against a panel of Gram-positive pathogens, including clinical MRSA strains, with MICs of 3–15 μg/mL; compounds 1 and 3 also were found to augment HIV-1 virus replication in a human lymphocyte model.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
