Neo-Clerodane diterpenoids from the aerial parts of Teucrium fruticans cultivated in China

Abstract

Seven neo-clerodane diterpenes, teufruintins A–G (1–7), together with eight known compounds (8–15) were isolated from the CHCl3-soluble fraction of the aerial parts of Teucrium fruticans cultivated in China. The chemical structures of the isolated compounds were elucidated using different spectroscopic methods. All of the isolated diterpenes were evaluated for their cytotoxic activities on three human cancer cell lines, and for their ability to inhibit LPS-induced nitric oxide production in RAW 264.7 macrophages. None of the compounds displayed cytotoxic activities on the cancer cell lines, and only 15 showed weak NO inhibitory activity.