Abstract
One of the most prevalent cancers in the world today is Squamous cell carcinoma of Head and Neck (HNSCC), which is distinguished by a physiologically heterogeneous group of tumors, non-specific biomarkers, and a dismal prognosis. Although the traditional surgical therapy methods have made positive strides, they results in long-term deformity, a shift in one's sense of self, and physically debilitating effects, whereas chemo and radiation therapy result in serious toxicities that have a detrimental influence on patients' quality of life. In order to enhance individual health outcomes and survival, neo-adjuvant therapeutic approaches were developed. Thus the current article reviews the various neo-adjuvant therapies and their significance in contrast to conventional surgery.
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