Abstract
Altered immunological reactivity occurred in mice infected with the larval stages ofNematospiroides dubius. This was shown by an increased responsiveness of mouse spleen lymphocytes and suppressed responsiveness of mesenteric lymph node (MLN) lymphocytes to phytohaemagglutinin (PHA) and concanavalin A (Con A) during the first 10–15 days after infection while at the same time spleen, MLN, and cervical lymph node (CLN) lymphocyte reactivity to lipopolysaccharide (LPS) was suppressed. Splenomegaly, with a marked increase of white pulp in the spleen, began 3 days after infection and there was a concomitant decrease in the numbers of cells in the MLN with depletion of the paracortical and medullary areas in particular.N. dubius larvae cultured in vitro produced a dialysable immunosuppressive factor which inhibited the proliferation of spleen lymphocytes from normal and immune mice and sheep in the presence of mitogens. Serum collected from infected mice also suppressed mitogen-induced transformation of normal mouse lymphocytes.
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