Abstract
Biological activities of Sorbus aucuparia L. leaves extract was tested in our study. Antineurodegenerative activity was evaluated by acetylcholinesterase (AChE) and tyrosinase (TYR) inhibitory activity assays while antioxidant activity was by tested using four different assays. In all antioxidant test we noticed concentration dependent activity of tested extract and the highest applied concentration of 500 μg/ml was the most active. Extract applied in concentration of 200 μg/ml showed higher percent of inhibition in DPPH test compared to both applied concentrations of standard substances BHA and BHT (50 and 100 μg/ml). In ABTS test, activity of extract applied in 500 μg/ml was comparable or higher then BHA and BHT/Vitamin C, respectively. Moreover, all concentrations of tested extract were significantly more active in s -carotene test than vitamin C. The lowest concentration of extract (100 μg/ml) was the most active in TYR assay reaching 42.57 % of the inhibition while in AChE assay there was not statistically significant differences among all applied concentrations.
Highlights
Genus Sorbus, Rosaceae is organized in four subgenera: Aria, Sorbus, Cormus and Torminaria that comprises about 250 species commonly distributed in the northern hemisphere with a colder climate
Antineurodegenerative activity was evaluated by acetylcholinesterase (AChE) and tyrosinase (TYR) inhibitory activity assays while antioxidant activity was tested using four different assays (DPPH, ABTS, Ferric-reducing ability of plasma (FRAP), and βcarotene test)
Different polyphenolic compounds such as phenolic acids, flavonols and their glycosides, flavan-3-ols etc. have been found in S. aucuparia (Kylli et al, 2010; Olszewska et al, 2012).Šavikin et al (2017a) have reported, carotenoids, tocopherols, and chlorophylls in berries from S. aucuparia collected in Serbia and Montenegro
Summary
Genus Sorbus, Rosaceae is organized in four subgenera: Aria, Sorbus, Cormus and Torminaria that comprises about 250 species commonly distributed in the northern hemisphere with a colder climate. Sorbus aucuparia is a tree widely distributed in the mountain regions of Europe and it is popular as an ornamental plant (Kylli et al, 2010) Different polyphenolic compounds such as phenolic acids, flavonols and their glycosides, flavan-3-ols etc. Very limited reports (Denev et al, 2014; Šavikin et al, 2017a) could be found regarding the chemical composition and biological activity of Sorbus species from Balkan Peninsula. Such reports for the leaves of S. aucuparia lack. Taking into account these facts, the aim of our work was to study antioxidant and antineurodegenerative activities of leaves of S. aucuparia collected on Stara Planina Mountain, Serbia
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