Abstract
The spread of Neisseria gonorrhoeae strains with reduced susceptibility to extended-spectrum cephalosporins is an increasing public health threat. Using Etest and multiantigen sequence typing, we detected sequence type 1407, which is associated with reduced susceptibilities to extended-spectrum cephalosporins, in 4 major populated regions in California, USA, in 2012.
Highlights
The spread of Neisseria gonorrhoeae strains with reduced susceptibility to extended-spectrum cephalosporins is an increasing public health threat
N. gonorrhoeae isolates with reduced susceptibility to extended-spectrum cephalosporins (ESCs) have been linked to altered penicillin-binding protein, Author affiliations: San Francisco Department of Public Health, San Francisco, California, USA
Antimicrobial drug susceptibility testing was performed by using Etest as part of the California rapid response project to enhance surveillance efforts aimed at detecting treatment failures and containing the spread of isolates that require increased MICs of third-generation cephalosporins
Summary
The spread of Neisseria gonorrhoeae strains with reduced susceptibility to extended-spectrum cephalosporins is an increasing public health threat. The increasing prevalence of isolates with reduced susceptibility to ESCs has led to dual treatment with ceftriaxone plus azithromycin or doxycycline. N. gonorrhoeae isolates with reduced susceptibility to ESCs have been linked to altered penicillin-binding protein, Author affiliations: San Francisco Department of Public Health, San Francisco, California, USA
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