Abstract
The semi-synthesis of melithiazol C (2b) has been accomplished in 4 steps and 41% overall yield starting from myxothiazol A (1a) produced by fermentation of Myxococcus fulvus. Key steps are a novel reductive cleavage of a thiazole ring by DIBAL-H and the conversion of the amide 2a into the methyl ester 2b via an imino ester. The biological activities of 2b and of derivatives of its 10-acetyl group are described.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
