Neighbourhood and mortality in severe mental illness

Ezra Susser,James B Kirkbride

doi:10.1016/s2215-0366(19)30164-6

Ezra Susser, James B Kirkbride

Open Access

https://doi.org/10.1016/s2215-0366(19)30164-6

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Abstract

Neighbourhood and mortality in severe mental illness

Highlights

10 Weiner DJ, Wigdor EM, Ripke S, et al Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
Evidence suggests that even in carriers of damaging mutations, common, inherited genetic variants might contribute to a proportion of the phenotypic variance,[10,11] and, in some instances, might modify the penetrance of rare variants.[12]
Neighbourhood social context is related to mortality, but whether such patterns exist for people with severe mental illness has received little attention

Summary

Introduction

10 Weiner DJ, Wigdor EM, Ripke S, et al Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders. The study by Jayati Das-Munshi and colleagues[3] in The Lancet Psychiatry represents a welcome step in that direction, linking higher neighbourhood ethnic density to lower mortality rates among people with severe mental illness from ethnic minority backgrounds.

Results

Conclusion