Abstract
Negishi cross-coupling reactions were used extensively in total synthesis. The expansion of substrate scope, the development of mild reaction conditions, the advancement of the methods to improve the stereo- and regio-selectivity of carbon-carbon bond formation, the maturity of a large number of sequential processes, and the development of non-toxic reactions signify the importance of Negishi coupling. The following review illustrates a strategic role of this reaction in constructing carbon-carbon bonds in the recent total synthesis of natural products.
Published Version
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