Abstract
Rhesus monkeys were trained to press a lever to extinguish a light associated with a drug infusion scheduled to occur 30 sec after the onset of the light. Each response during the light period terminated the light for a 1-min time-out period (avoidance); a response during the infusion terminated the infusion (escape). Under these conditions the monkeys tolerated a high number of saline infusions. Saline was replaced by different unit doses of nalorphine, cyclazocine, naloxone, cocaine, codeine, pentazocine and propiramfumarate each for six successive daily 2-h sessions.
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