Negative penicillin skin testing induced anaphylaxis with concurrent beta blocker and angiotensin-converting enzyme inhibitor use

Abstract

Penicillin allergy occurs at a prevalence rate of 0.7% to 10% in adults and children.1 Hypersensitivity to penicillin is typically evaluated with a protocol that consists of skin testing with skin prick and intradermal tests, followed by an oral amoxicillin challenge if the former test results are negative.2,3 Recent studies have revealed that drug hypersensitivity may be directly evaluated by an oral challenge without a preceding skin test in low-risk populations.4,5 We present the first case of anaphylaxis following negative results of skin prick and intradermal tests with penicillin and benzylpenicilloyl polylysine.