Abstract
SHP-1 is the protein tyrosine phosphatase which is mainly expressed in the cytoplasm of hematopoietic-derived cells,and it is the key factor to change the levels of intracellular phosphorylation.SHP-1 can generate different intracellular signals in different cells,and it can play various functions. Key words: Protein-tyrosine kinases; Signal transduction; Immune system; Hematopoietic system
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