Nefrotik Sendroma Öncelik Eden Multipl Miyeloma

Abstract

Membranoproliferative glomerulonephritis (MPGN) is the most common cause of nephrotic syndrome in young adults. This is a unique clinical entity developing secondary to autoimmune disorders or infections, and renal failure may be the presenting feature of the disease. Here we reported a case with nephrotic syndrome (NS) diagnosed 2 years before with multiple myeloma (MM). At the beginning, hypertension, edema, anemia, moderate renal failure, hypoalbuminemia, severe proteinuria and dyslipidemia were found. She was treated with prednisolone plus conservative measures including anti-hypertensives, angiotensin converting enzyme inhibitor (ACEI), dipyridamol and low salt diet. Two years later, MM was detected and treated with anti-neoplastic agents. Remission was achieved both for the MM and for the renal disease. At the end of 4 years after the diagnosis of MM, relapse occurred without renalfailure. It is known that NS accompanies to MM, but NS preceding MM is very rare. For this reason, the possibility of the development of a malignant disease should be considered in cases with idiopathic glomerulonephritis.