Abstract
Background HIV infection of the thymus results in a decreased output of naive T cells. We previously showed that expression of the Nef protein alone is sufficient to disturb human thymopoiesis. Additional structure-function studies with mutant Nef alleles suggested a role of PAK2 in this process. In this study we evaluated the effect of Nef alleles from different clinical HIV-1, HIV-2 and SIV isolates and Nef mutants which were specifically mutated in the PAK2 interaction surface for their effect on T cell development.
Highlights
HIV infection of the thymus results in a decreased output of naive T cells
Nef interferes with development of thymic T cell precursors: differential mechanisms in HIV and SIV
We previously showed that expression of the Nef protein alone is sufficient to disturb human thymopoiesis
Summary
HIV infection of the thymus results in a decreased output of naive T cells. We previously showed that expression of the Nef protein alone is sufficient to disturb human thymopoiesis. Additional structure-function studies with mutant Nef alleles suggested a role of PAK2 in this process. In this study we evaluated the effect of Nef alleles from different clinical HIV-1, HIV-2 and SIV isolates and Nef mutants which were mutated in the PAK2 interaction surface for their effect on T cell development
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