Needle revision and suture cut combined with subconjunctival injection with 5-FU for treatment of earlier postoperative non-filtering blebs with high IOP

Abstract

Objective To investigate the efficacy of bleb needle revision and suture cut with 5-FU subconjuctival injection near the bleb in reviving earlier non-filtering blebs with high lOP after glaucoma filtra-tion surgery. Methods Eighteen eyes of earlier non-filtering blebs with high lOP after glaneoma filtration surgery were treated with the technique of bleb needle separating adherence and cutting the suture of seleral flap with 5-FU subconjuctival injection near the bleb. Results Eleven eyes needed only once needle revision and suture cut,4 eyes repeated the therapeutics and 3 eyes failed at once. With 6-month follow-up,the IOP of 10 eyes were below 21 mmHg without any anti-glancoma drugs, 2 eyes needed adding 1-2 kinds of anti-glaucoma drugs, 1 eye needed 3 kinds of drugs,and 2 eyes needed re-operation to control the IOP below 21mmHg.With 12-month follow-up,the IOP of 8 eyes were below 21mmHg without any anti-glaucoma drugs,3 eyes needed adding 1-2 kinds of anti-glancoma drugs,2 eyes without follow-up. The mean IOP was 29.4±9.4mmHg before the treatment and that was 14.5±5.7mmHg after 6 months of the treatment,the difference was significant (P< 0.01 ). Conelusion It is safe and effective to treat earlier non-filtering blebs with high IOP after glaucoma filtration surgery with needle revision and suture cut combined with subconjunctival injection with 5-Fu, and it can be used as the routine method to treat the complication of earlier non-filtering blebs with high IOP. Key words: Needle revision; Glaucoma; Filtering bleb; Suture eut; 5-Fu