Abstract
Sleep Sleep is crucial for healthy living and well-being, but individual sleep needs vary greatly. Xing et al. performed whole exome sequencing in a family of short sleepers and identified a point mutation in the neuropeptide S receptor 1 gene ( NPSR1 ) responsible for the short sleep phenotype. The mutation increased receptor sensitivity to the endogenous ligand. Mice carrying the mutation showed increased mobility time, reduced sleep duration, and resistance to sleep deprivation–induced cognitive impairment. NPSR1 may thus play a major role in sleep-related memory consolidation. Sci. Transl. Med. 11 , eaax2014 (2019).
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