Abstract
Ectopic hamartomatous thymoma is a rare neoplasm with classic anatomical location and characteristic histological and immunohistochemical features. Awareness of ectopic hamartomatous thymoma is essential to accurately diagnose these lesions which clinically mimics lipoma. Based on the morphologic and immunophenotypic features, the authors stress the need to discontinue the existing term of ectopic hamartomatous thymoma and replacing it with suitable nomenclature that aptly denotes its phenotype and possible histogenesis. The authors propose a new terminology “Triphasic Epithelial Myoepithelial Mesenchymal Branchial Anlage Tumor” as it encompasses three important constituents of the lesion (epithelial, myoepithelial, and mesenchymal) and its possible histogenesis in relation to branchial remnants.
Highlights
Ectopic hamartomatous thymoma is a rare tumor occurring in the lower part of the neck
We describe in detail its histopathological and immunohistochemical features, its possible histogenesis, and a review of relevant literature
We propose a new terminology “Triphasic Epithelial Myoepithelial Mesenchymal Branchial Anlage Tumor (TEMMBAT)” as it encompasses three important constituents of the lesion and its possible histogenesis in relation to branchial remnants
Summary
Ectopic hamartomatous thymoma is a rare tumor occurring in the lower part of the neck It is a benign tumor consisting of variable admixture of adipose tissue, spindle cells and epithelial islands. We report one such case in which a subcutaneous suprasternal mass clinically and radiologically mimicking lipoma was observed. It was observed that there was a subcutaneous mass in the suprasternal notch, of soft consistency. It was seen that the tumor was composed of mature adipose tissue, spindle cells, and epithelial component in varying proportions (Figure 2). The epithelial component was observed as consisting of stratified squamous epithelium arranged in anastomosing cords, solid nests, and islands. The areas between the plump spindle cells surrounding the epithelial islands and mature adipose tissue showed delicate fibroblast-like spindle cells mixed with. The follow-up examination of the patient showed no evidence of recurrence or metastasis after 6 months of resection
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