Abstract
Glatiramer acetate (GA) is an approved and well tolerated drug for the treatment of relapsing–remitting multiple sclerosis. We report a case of a 52year-old man with psoriasis and relapsing–remitting multiple sclerosis who developed, after 21months of GA treatment, an injection-site cutaneous necrosis that involved both subcutaneous and muscular tissue with massive edema, followed, 3days later, by radial nerve palsy. After few days another similar lesion appeared in another injection-site. We hypothesize that cutaneous necrosis could be due to a local dis-immune reaction and, probably, psoriasis could have played an important role in its pathogenesis.
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