Abstract
Necrotizing sialometaplasia (NS) is an uncommon, self-limiting inflammatory disease of the salivary glands (SG). We report the case of a 55-year-old woman with 2 asymptomatic ulcers on the hard palate for 1 month, with no causative factor. The patient had a diagnosis of diabetes mellitus type 2, hypertension, and hypertensive renal disease and was taking prednisone (50 mg/day), acetylsalicylic acid (100 mg/day), insulin, metformin (850 mg/twice/day) and a combination of 5 antihypertensives. Incisional biopsy followed by histopathologic analysis revealed epithelial hyperplasia and superficial ulceration, mucin spillage into the stroma associated with mixed inflammatory infiltrate, and mucinous acini next to SG ducts containing squamous metaplasia. Polymerase chain reaction for cytomegalovirus, Epstein-Barr virus, and herpesvirus types 1, 2, and 6 were negative. The final diagnosis was NS and the patient experienced complete healing in 3 months after the biopsy. Although we could not determine any local causative factor, it is possible that the patient's complex systemic condition contributed for the lesions' development.
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