Abstract
Both patent ductus arteriosus (PDA) and packed red blood cell (PRBC) transfusion are risk factors for necrotizing enterocolitis (NEC). The combination of PDA and PRBC transfusion may have a synergistic effect on the intestinal circulation. We present four cases of NEC in very low birth weight (VLBW) infants within 14 h after PRBC transfusion. All infants were growing on full enteral feeding, and they all had a PDA. We are concerned that the simultaneous presence of a PDA and PRBC transfusion in VLBW infants may place the infant at even greater risk of NEC than each of these factors alone.
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