Abstract
Infective endocarditis (IE) and small-vessel vasculitis may have similar clinical features, including glomerulonephritis. Furthermore the association between IE and ANCA positivity is well documented, making differential diagnosis between IE- and ANCA-associated vasculitis particularly difficult, especially in case of culture-negative IE. We report on one patient with glomerulonephritis secondary to culture-negative IE caused by Bartonella henselae which illustrates this diagnostic difficulty.
Highlights
Infective endocarditis (IE) and small-vessel vasculitis may have a similar clinical presentation
We report on one patient with glomerulonephritis secondary to culture-negative IE caused by Bartonella henselae which highlights this diagnostic difficulty
Among the causes of infection-related glomerulonephritis in adults, 6–20% are related to endocarditis [3] and glomerulonephritis is considered as a minor Duke criterion for the diagnosis of IE [4]
Summary
Necrotizing ANCA-Positive Glomerulonephritis Secondary to Culture-Negative Endocarditis. Sophie Van Haare Heijmeijer, Dunja Wilmes, Selda Aydin, Caroline Clerckx, and Laura Labriola. Infective endocarditis (IE) and small-vessel vasculitis may have similar clinical features, including glomerulonephritis. The association between IE and ANCA positivity is well documented, making differential diagnosis between IE- and ANCAassociated vasculitis difficult, especially in case of culture-negative IE. We report on one patient with glomerulonephritis secondary to culture-negative IE caused by Bartonella henselae which illustrates this diagnostic difficulty
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