Abstract
Background:Apomorphine is a potent dopamine agonist used in the treatment of advanced and fluctuating Parkinson’s Disease. However the need for its subcutaneous infusion can lead to skin reactions.Phenomenology Shown:We illustrate necrotic ulcers at infusion sites as a rare event during continuous subcutaneous apomorphine infusion.Educational value:This case demonstrates the rare adverse event of necrotic ulcers in a patient with long term apomorphine infusion.
Highlights
Apomorphine is a potent dopamine agonist used in the treatment of advanced and fluctuating Parkinson’s Disease
We describe an 81 year-old man with a 17 year history of levodopa responsive Parkinson’s Disease (PD), treated with Continuous Subcutaneous Apomorphine Infusion (CSAI) at rate of 5 mg/hour × 12 hours daily for 3 years
Another report noted similar results in a young patient with longstanding PD, which resolved over one month following discontinuation [1, 2]
Summary
Apomorphine is a potent dopamine agonist used in the treatment of advanced and fluctuating Parkinson’s Disease. CORRESPONDING AUTHOR: Dr Yudy Llamas-Osorio, MD Department of Neurology, Mater Misericordiae University Hospital, 57 Eccles Street, Dublin 7, IE yudyllamasosorio@mater.ie TO CITE THIS ARTICLE: Llamas-Osorio Y, McLoughlin C, Maguire M, Lynch T.
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