Abstract
Infant hamsters succumbed 8 days after intraperitoneal inoculation with louping-ill virus. Necrosis of cerebellar neurons resulted directly from growth of virus within neuronal cytoplasm. Viral antigen was first demonstrated by immunofluorescence on day 3, and virus particles were detected ultrastructurally from day 4. In moribund hamsters almost all cerebellar neurons contained virus. Virus particles were always enclosed in abnormal cytoplasmic membranes, which remained intact even in disintegrating cells. Numerous foam cells were seen late in the course of the disease and phagocytosed material was apparent in pericytes. Blood vessels remained intact and endothelial cells did not appear to be involved.
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