Abstract
BackgroundNeck circumference (NC) has been previously related to cardiometabolic risk factors. In this study we examined the association between NC and early stage atherosclerosis in Chinese adults.MethodsThe study samples were from a community-based health examination survey in central China. In total 2,318 men and women (18-64 y) were included in the final analyses. Carotid radial pulse wave velocity (crPWV), carotid femoral PWV (cfPWV), carotid artery dorsalis pedis PWV (cdPWV) and NC were measured.ResultsAfter adjustment for age, sex, lipids, glucose, blood pressure, heart rate, body mass index (BMI), high NC was significantly associated with an increasing trend of cfPWV, cdPWV and crPWV (P = 0.001, 0.049, and 0.038; respectively). In addition, we found significant interaction between hypertension status and NC level in relation to cfPWV, adjusted for age, sex, BMI, fasting glucose, lipids and heart rate(P for interaction = 0.034). The associations between NC and cfPWV were significant (P = 0.02) among those with hypertension, but not significant among those without hypertension.ConclusionsOur data showed that high NC was associated with an increased risk of early stage atherosclerosis in Chinese adults, independent of other metabolic risk factors. Hypertension might modify the association between NC and cfPWV.
Highlights
IntroductionIn this study we examined the association between Neck circumference (NC) and early stage atherosclerosis in Chinese adults
Neck circumference (NC) has been previously related to cardiometabolic risk factors
PWV measured at different sites may reflect the atherosclerotic alterations at central (e.g. carotid femoral pulse wave velocity) or peripheral arteries (e.g. carotid artery dorsalis pedis pulse wave velocity and carotid radial pulse wave velocity). carotid femoral PWV (cfPWV) is recognized as the “gold standard” parameter for the evaluation of arterial stiffness and has had a wide biomedical application [11,12]
Summary
In this study we examined the association between NC and early stage atherosclerosis in Chinese adults. Few studies have assessed the relation between NC and early stage atherosclerosis in Chinese adults [5]. PWV is a gold standard for assessing arterial stiffness, and has been widely used as an indicator for early-staged atherosclerosis [7,8,9,10]. PWV measured at different sites may reflect the atherosclerotic alterations at central (e.g. carotid femoral pulse wave velocity (cfPWV)) or peripheral arteries (e.g. carotid artery dorsalis pedis pulse wave velocity (cdPWV) and carotid radial pulse wave velocity (crPWV)). The analysis of the peripheral pulse wave (cdPWV and crPWV) can provide parameters with different meanings in the arterial dynamics, some already used to assess the arterial stiffness [13,14]
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