Abstract
The results of several recent investigations on the role of cholesterol in myelin, appear to indicate that the synthesis and maintenance of myelin is achieved by at least three processes: a) recycling of molecules within the nervous system; b) synthesis of new molecules, and c) incorporation of exogenous material. Although synthesis of cholesterol, which is very high during rapid myelination, deereases to very low levels in the adult animal, uptake of exogenous cholesterol by myelin occurs not only during myelination but also in the adult animal.Whether exogenous and endogenous cholesterol molecules accomplish different roles in the development of the nervous system in general and in the formation and maintenance of the myelin sheaths in particular is still unknown.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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