Nebulized CLODOS Technology Shows Clear Virucidal Properties against the Human Coronavirus HCoV-229E at Non-Cytotoxic Doses.

Sabina Andreu,Raquel Bello-Morales,Inés Ripa,José Antonio López-Guerrero

doi:10.3390/v13030531

Abstract

The emergent human coronavirus SARS-CoV-2 and its high infectivity rate has highlighted the strong need for new disinfection systems. Evidence has proven that airborne transmission is an important route of spreading for this virus. Therefore, this short communication introduces CLODOS Technology®, a novel strategy to disinfect contaminated surfaces. It is a product based on stable and 99% pure chlorine dioxide, already certified as a bactericide, fungicide and virucide against different pathogens. In this study, CLODOS Technology®, by direct contact or thermonebulization, showed virucidal activity against the human coronavirus HCoV-229E at non-cytotoxic doses. Different conditions such as nebulization, exposure time and product concentration have been tested to standardize and optimize this new feasible method for disinfection.

Highlights

The Coronaviridae are a large family of lipid-enveloped, single-stranded positivesense RNA viruses that can cause respiratory, gastrointestinal, hepatic and neurological problems both in humans and animals [1]
There is strong evidence that airborne transmission is a significant factor in the spread of SARS-CoV-2, and that the accumulation of infectious bioaerosols in spaces with poor ventilation contributes to the transmission of the virus [11,12]
Face masks and social distancing help to reduce this route of transmission, further precautions specific to aerosols are required

Summary

Introduction

The Coronaviridae are a large family of lipid-enveloped, single-stranded positivesense RNA viruses that can cause respiratory, gastrointestinal, hepatic and neurological problems both in humans and animals [1]. Airborne transmission or aerosols are produced when particles named “droplet nuclei” (smaller than 5–10 μm in diameter) remain suspended in the air for a variable period of time [8] and may be transported over considerable distances [9]. These aerosols can be generated from normal breathing and from the evaporation of larger droplets produced by coughing and sneezing by both asymptomatic and symptomatic people [10,11]. Face masks and social distancing help to reduce this route of transmission, further precautions specific to aerosols are required

Objectives

Methods

Results

Conclusion