Abstract
In the past decade, great advances have been achieved for the biomedical application of gold (Au) nanostructures. Due to their unique physicochemical properties, Au nanostructures have been extensively explored for their use in cancer cell imaging, photothermal therapy, as well as drug/gene delivery. The facile control of synthesis and surface functionalization help the construction of multifunctional Au nanostructures for cancer diagnosis and treatment. Recently, Au nanostructure-based theranostic platforms have been extensively explored, and great advantages have been demonstrated. This chapter summarizes the recent progress of Au nanostructures as contrast agents for cancer imaging, as therapeutic composites for photothermal therapy and drug/gene delivery, and as multifunctional theranostic platform for cancer. The surface functionalization of Au nanostructures including noncovalent and covalent modification will also be discussed. We focus on the near-infrared (NIR) light-mediated cancer theranostics using Au nanostructures including Au nanoshells (AuNSs), Au nanorods (AuNRs), hollow Au nanospheres (HAuNSs), and Au nanocages (AuNCs).
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