Near-infrared fluorescent probe for sensitive detection of Pb(II) ions in living cells

Jianheng Bi,Mingxi Fang,Jianbo Wang,Shuai Xia,Yibin Zhang,Jingtuo Zhang,Giri Vegesna,Shuwei Zhang,Marina Tanasova,Fen-Tair Luo,Haiying Liu

doi:10.1016/j.ica.2017.06.044

Near-infrared fluorescent probe for sensitive detection of Pb(II) ions in living cells

Jianheng Bi, Mingxi Fang + Show 9 more

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https://doi.org/10.1016/j.ica.2017.06.044

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Journal: Inorganica Chimica Acta	Publication Date: Jun 20, 2017
Citations: 28

Affiliation: Michigan Technological University, Institute of Chemistry, Academia Sinica, Jiaxing University

#Fluorescent Probe For Sensitive Detection #Pb Ions + Show 8 more

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Abstract

A new near-infrared fluorescent probe (NIR-PbP) for sensitive detection of Pb(II) ions in solution and living cells has been rationally designed and synthesized. The NIR-PbP is inherently non-fluorescent and gains fluorescence in the presence Pb(II) ions. The ion detection is based on Pb(II)-induced unmasking the fluorophore through the opening of the spyrocycle, with more than 500-fold fluorescence enhancement for sub-micromolar Pb(II) concentration. The NIR-PbP has high sensitivity, good photo-stability, low detection limit, and reversible response to Pb(II) ions.

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