Abstract
The initiation of the Human Genome Project in 1991 generated a lot of activity in the field of DNA sequencing [1]. It accelerated not only the generation of data on the human and other model genomes but also the development of better technology and automation for obtaining the sequencing data. The sequencing technique developed by Sanger et al. [2] using dideoxynucleotide terminators is the method of choice for automated DNA sequencing. Today automated DNA sequencers are available that encompass a wide spectrum of technologies. The technology most widely used today was initially developed and marketed by Applied Biosystems (now PE Biosystems) in the 1980s. With it, the sequence fragments are detected in the visible region of the electromagnetic spectrum using visible fluorophores [3].
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