Abstract
The near-complete genome sequence of foot-and-mouth disease virus (FMDV) serotype A potential vaccine strain BAN/CH/Sa-304/2016 is reported here. Its genome revealed antigenic heterogeneity with the current Indian vaccine strain IND40/00, with four amino acid substitutions in antigenically critical sites of the VP1 protein.
Highlights
Foot-and-mouth disease (FMD) is a highly contagious disease of domestic and wild cloven-hoofed animals worldwide [1]
Vaccination is the main tool for controlling FMD in areas of endemicity, but repeated vaccine failure in Bangladesh warrants an effective vaccine tailored to circulatory serotypes [4, 6]
We proposed Foot-and-mouth disease virus (FMDV) serotype A isolate BAN/CH/Sa-304/2016 as a potential vaccine strain based on a two-dimensional microneutralization test (2D-MNT) and a strong antigenic relationship with contemporary serotype A strains of Bangladesh (r Ͼ 0.3) [7]
Summary
Foot-and-mouth disease (FMD) is a highly contagious disease of domestic and wild cloven-hoofed animals worldwide [1]. We proposed FMDV serotype A isolate BAN/CH/Sa-304/2016 as a potential vaccine strain based on a two-dimensional microneutralization test (2D-MNT) and a strong antigenic relationship with contemporary serotype A strains of Bangladesh (r Ͼ 0.3) [7]. The serotype A strain BAN/CH/Sa-304/2016 was isolated from tongue tissue of an infected cow, collected on 29 September 2016 from a military dairy farm in Chittagong, Bangladesh.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
