Abstract

Articular cartilage is avascular and has limited capacity for repair. In diseased conditions such as osteoarthritis, there is an increase in water content from the average normal of 60–85% to greater than 90%. As cartilage has very little capability for self-repair, methods of early detection of degeneration are required, and assessment of water could prove to be a useful diagnostic method. Non-destructivenear infrared spectroscopyis extremely sensitive to the chemical composition and molecular structure of tissues and could prove to be a useful method for early diagnosis of cartilage degeneration. The hypothesis that NIR spectra can be used to assess water content in cartilage was investigated in the current study.

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