Abstract
Rapid growth of nanotechnology is one of the most quickly emerging tendencies in cancer therapy. Gold nanoparticles roused a distinctive interest in the field, due to their incomparable light-to-thermal energy conversion efficiency, and their ability to load and deliver a variety of anticancer drugs. Therefore, simultaneous photothermal (PTT) and photodynamic (PDT) cancer therapy is available by the role of the thermal agent of the gold nanoparticle itself and the drug delivery carrier for photosensitizer (PS) transport. In this review, the physical, chemical, and biological properties of gold nanoparticle, which can promote PTT and PDT efficiency, are briefly demonstrated, and we highlight recent progression in the development of PS-containing gold nanocomposites for effective cancer therapy.
Highlights
Photothermal therapy (PTT) and photodynamic therapy (PDT) are promising cancer treatments in which the heat generation of nanoparticles and the activation of photosensitizer (PS) drugs occurs in response to exogenously applied specific wavelengths of light
Certain types of tumor targeting can be enhanced with gold nanoparticles that have significant nano-scale benefits that can be accumulated in tumor tissue by the enhanced permeability and retention (EPR) effect of the tumor microenvironment [4]
In the endosomes of cells, mesenchymal stem cells (MSCs), which enable the aggregation of pH-sensitive gold nanoparticles (PS-AuNPs), can be vectors for photothermal therapy, and they can especially be used for target tumors, which reveals a mild-acidic environment
Summary
Photothermal therapy (PTT) and photodynamic therapy (PDT) are promising cancer treatments in which the heat generation of nanoparticles and the activation of photosensitizer (PS) drugs occurs in response to exogenously applied specific wavelengths of light. Recent studies have shown that photothermal (PTT) and photodynamic (PDT) treatments that respond to near-infrared (NIR) wavelength lasers through the combination of multifunctional plasmon nanoparticles and fluorescent photodynamic agents can achieve a synergistic effect for tumor therapy [5,6,7,8]. Much effort has been devoted to the development of dual to accomplish their tumor therapeutic effects. Much effort has been devoted to the development of to accomplish their tumor therapeutic effects. PDT, and we of gold nanoparticles and species of photosensitizer (PS) to accomplish PTT and PDT, andlastly lastly we academicon developments and advances.
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