Near infrared light-responsive and drug-loaded black phosphorus nanosheets for antibacterial applications

Abstract

The management of wound infection remain a major global challenge, effectively ablation of bacteria is of significant in fighting wound infectious diseases. Herein, black phosphorus nanosheets (BPNSs) were successfully prepared by liquid phase exfoliation technology, and composite nanosheets (BPNSs@phy) were formed by loading antimicrobial physcion（Phy）via hydrophobic interaction. Studies have shown that BPNSs@phy has good stability and low cytotoxicity under physiological conditions. In addition, BPNSs@phy has excellent photothermal conversion ability. After the irradiation of 808 nm near-infrared light, the light energy is converted into heat to promote the release of physcion. Under the synergistic effect of photothermal therapy (PTT) and antibacterial agents, BPNSs@phy has an excellent bactericidal effect against S.aureus (99.7%) and P.aeruginosa (99.9%). This study is expected to provide a new strategy for the development of BPNSs based antibacterial materials.