Abstract
Lipid droplets (LDs) are important organelles with hydrophobic structure that not only served the function of lipid storage in cells but also participate in the regulation of numerous metabolic processes. Broad visualization of LDs with high brightness is important for biological applications. In this study, three novel facile near-infrared aggregation-induced emission (AIE) fluorescent bioprobes based on triphenylamine-pyridine building block were designed and synthesized. These AIEgens block exhibits tunable D-D-π-A (D: donor, A: acceptor) structure with twisted intramolecular charge transfer (TICT) characteristics. These bioprobes can highly light up LDs in the living cells, model animal zebrafish and shelled sunflower seed. More importantly, these probes can effectively produce reactive oxygen species (ROS) in the presence of light irradiation, leading to the apoptosis of cancer cells. This study exhibits promising applications in photodynamic therapy through targeting LDs.
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