Abstract
Near-infrared (NIR) multifunctional BODIPY-Platinum (BODIPY-Pt) conjugates were synthesized, which compose of fluorescent borondipyrromethene (BODIPY) dyes and therapeutic agents of cisplatin. BODIPY-Pt conjugates combined the NIR imaging, photodynamic therapy (PDT) and chemotherapy in one. BODIPY-Pt possesses the excellent phototoxicity at low concentration upon radiation and comparable chemotherapeutic toxicity with cisplatin. The cellular uptake and distribution were validated by confocal laser scanning microscopy. In addition, the in vivo studies on bearing U14 tumor-bearing mice demonstrated that the BODIPY-Pt conjugates simultaneously keep the fluorescent imaging and antitumor effect.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
