Abstract
BackgroundCartilage elasticity changes with cartilage degeneration. Hence, cartilage elasticity detection might be an alternative to traditional imaging methods for the early diagnosis of osteoarthritis. Based on the wave propagation measurement, Shear wave elastography (SWE) become an emerging non-invasive elasticity detection method. The wave propagation model, which is affected by tissue shapes, is crucial for elasticity estimating in SWE. However, wave propagation model for cartilage was unclear.MethodsThis study aimed to establish a wave propagation model for the cartilage-bone structure. We fabricated a cartilage-bone structure, and studied the elasticity measurement and wave propagation by experimental and numerical Lamb wave method (LWM).ResultsResults indicated the wave propagation model satisfied the lamb wave theory for two-layered structure. Moreover, a near field region, which affects wave speed measurements and whose occurrence can be prevented if the wave frequency is larger than one critical frequency, was observed.ConclusionOur findings would provide a theoretical foundation for further application of LWM in elasticity measurement of cartilage in vivo. It can help the application of LWM to the diagnosis of osteoarthritis.
Highlights
The objective of this study is to develop the Lamb wave method (LWM) for elasticity measurement in cartilage-bone structure
To prevent occurrence of the near field effect and measure a valid wave speed, the wave frequency should be higher than the critical frequency
Lamb wave method shows a potential for elasticity detection of cartilage
Summary
Cartilage elasticity detection might be an alternative to traditional imaging methods for the early diagnosis of osteoarthritis. Based on the wave propagation measurement, Shear wave elastography (SWE) become an emerging non-invasive elasticity detection method. The wave propagation model, which is affected by tissue shapes, is crucial for elasticity estimating in SWE. Wave propagation model for cartilage was unclear. Early treatment, including preventing and even reversing the pathological changes of osteoarthritis, is desired. It is well established that the initial pathologic change observed in cartilage degeneration is focal glycosaminoglycan depletion. It changes the elastic properties of cartilage whereas the morphological appearance
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