Near-Complete Genome Sequence of a Potential Foot-and-Mouth Disease Virus Serotype A Vaccine Strain Isolated from Bangladesh.

M Al Amin,M Anwar Hossain,Munawar Sultana,M Rahmat Ali,Mohammad Anwar Siddique,Huzzat Ullah,A S M Rubayet Ul Alam,Jelle Matthijnssens

doi:10.1128/mra.00031-19

Abstract

The near-complete genome sequence of foot-and-mouth disease virus (FMDV) serotype A potential vaccine strain BAN/CH/Sa-304/2016 is reported here. Its genome revealed antigenic heterogeneity with the current Indian vaccine strain IND40/00, with four amino acid substitutions in antigenically critical sites of the VP1 protein.

Highlights

Foot-and-mouth disease (FMD) is a highly contagious disease of domestic and wild cloven-hoofed animals worldwide [1]
Vaccination is the main tool for controlling FMD in areas of endemicity, but repeated vaccine failure in Bangladesh warrants an effective vaccine tailored to circulatory serotypes [4, 6]
We proposed Foot-and-mouth disease virus (FMDV) serotype A isolate BAN/CH/Sa-304/2016 as a potential vaccine strain based on a two-dimensional microneutralization test (2D-MNT) and a strong antigenic relationship with contemporary serotype A strains of Bangladesh (r Ͼ 0.3) [7]

Summary

Introduction

Foot-and-mouth disease (FMD) is a highly contagious disease of domestic and wild cloven-hoofed animals worldwide [1]. We proposed FMDV serotype A isolate BAN/CH/Sa-304/2016 as a potential vaccine strain based on a two-dimensional microneutralization test (2D-MNT) and a strong antigenic relationship with contemporary serotype A strains of Bangladesh (r Ͼ 0.3) [7]. The serotype A strain BAN/CH/Sa-304/2016 was isolated from tongue tissue of an infected cow, collected on 29 September 2016 from a military dairy farm in Chittagong, Bangladesh.

Results

Conclusion