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Abstract
A phytochemical study of the bark of Alseodaphne perakensis has yielded three aporphine alkaloids: the new compound N-cyanomethylnorboldine (1), and the two known alkaloids N-methyllaurotetanine (2) and norboldine (3). The isolation was achieved by chromatographic techniques and the structural elucidation was performed via spectral methods, notably 1D- and 2D-NMR, UV, IR, and HRFABMS. The vasorelaxation activity of compound 1 has been studied.
Highlights
IntroductionAlseodaphne perakensis (Gamble) Kosterm from the family Lauraceae is a small tree of about 6 meters in height and with yellow-green flowers, distributed mainly in Peninsular Malaysia
Alseodaphne perakensis (Gamble) Kosterm from the family Lauraceae is a small tree of about 6 meters in height and with yellow-green flowers, distributed mainly in Peninsular Malaysia.Alseodaphne species have been reported to contain bisbenzylisoquinolines [1] and oxobisbenzylisoquinolines [2]
7.89 which correspond to H-3, H-8 and H-11, indicating the compound was an aporphine alkaloid [3]
Summary
Alseodaphne perakensis (Gamble) Kosterm from the family Lauraceae is a small tree of about 6 meters in height and with yellow-green flowers, distributed mainly in Peninsular Malaysia. Alseodaphne species have been reported to contain bisbenzylisoquinolines [1] and oxobisbenzylisoquinolines [2]. We report the isolation and characterization of a new aporphine alkaloid, N-cyanomethylnorboldine (1), together with the known aporphines N-methyllaurotetanine (2). Norboldine (3) (Figure 1) from the bark of Alseodaphne perakensis collected at Sg. Merantor, Gua
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