Abstract
Digestive system cancer remains a common cancerand the main cause of cancer-related death worldwide. Drug resistance is a major challenge in the therapy of digestive system cancer, andrepresents a primary obstaclein the treatment of cancer by restricting the efficiency of both traditional chemotherapy and biological therapies. Existing studiesindicatethat noncoding RNAs play an important role in the evolution and progression of drug resistance in digestive system cancer, mainly by modulating drug transporter-related proteins, DNA damage repair,cell-cycle-related proteins, cell apoptosis-related proteins, drug target-related proteins, and the tumor microenvironment. In this review, we address the potential mechanisms of ncRNAs underlying drug resistance in digestive system tumors and discuss the possible application of ncRNAs against drug resistance in digestive system tumors.
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