Abstract
We investigated in patients with sleep disordered breathing the influence of long-term nCPAP-therapy on airway mechanics and capillary blood gases. 109 patients (19 women, 90 men, age [mean +/- standard deviation] 59 +/- 10 years, apnea-hypopnea-index 34 +/- 24/h) were treated for 27 +/- 33 months, with a mean pressure of 7.7 +/- 2 mbar, mean usage 5.6 +/- 1.9 h/night. Vital capacity, FEV1, thoracic gas volume and capillary blood gases did not change during therapy, irrespective of the smoking history. However, in a subgroup of 6 patients who were hypoxemic before therapy, there was a significant increase of PaO2 from 63 +/- 4 to 70 +/- 6 mm Hg (p < 0.01). Neither the height of the pressure nor the duration of therapy did influence the course of lung function data.
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