NCOVID -19 pandemic outbreak in India - A concise review

Abstract

The beginning of 2021 has seen outbreaks of novel coronavirus COVID-19 infections, which have become a global pandemic. It is considered to have higher contagiousness and mortality compared to SARS and MERS. Clinical manifestations of nCOVID-19 symptoms are identified as coughs, fevers, vomiting, chills, joint pain, shortness of breath, and diarrhea. Older people over 70 years of age and those with chronic debilitating diseases such as end-stage illness, diabetes mellitus, hypertension, and pulmonary diseases are at a higher risk of mortality from nCOVID-19 infection. Currently, no specific approved antiviral drugs are available against nCOVID-19. Considering this imminent need, scientists and physicians have been racing to better understand this new pandemic virus-specific mechanism; pathophysiology, and target site of the disease to find effective therapeutic agents and vaccines. This review summarised the origin, transmission, clinical symptoms, and conventional outcome treatment strategies of infection. It also included a discussion of the potential for recurrence. In our study, we emphasised reported potential repurposing drugs that are effective against SARS, MERS, and nCOVID-19, among other diseases. Our early knowledge will provide an overview of the intelligence basis work for currently existing therapeutic vaccines against nCOVID-19 that will be useful in the development of future vaccines.