Abstract
The Nazarov reagent (ethyl-3-oxo-4-pentenoate) is frequently used as an annulating agent in many important reactions. Annulation reaction comprises Michael and Aldol condensations and is used for the construction of molecular scaffolds which constitute the core structure of many natural products. This reagent generates different classes of natural products, mainly steroids, cardenolides, terpenoids, antibiotics and alkaloids. Modified Nazarov reagents have been used for generating diverse chemical scaffolds. [1]
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